This label denotes the neuronal cell bodies and fibers detected by immunohistochemistry in the study's rat brain mapping experiment.
First-pass extracted concept
preprohypocretin-immunoreactive neurons and fibers
Candidate: concept label1 source documents6 linked claims
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Aliases
preprohypocretin-immunoreactive fibers, preprohypocretin-immunoreactive neurons, preprohypocretin-positive neurons
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Linked Claims
Preprohypocretin-positive cells were distinct from cells that express melanin-concentrating hormone.
Quoted textsource-backed
These cells were distinct from those that express melanin-concentrating hormone.
The anatomical distribution results suggest that hypocretins are likely to have physiological roles beyond food intake, including regulation of blood pressure, the neuroendocrine system, body temperature, and the sleep-waking cycle.
Quoted textsource-backed
These results suggest that hypocretins are likely to have a role in physiological functions in addition to food intake such as regulation of blood pressure, the neuroendocrine system, body temperature, and the sleep-waking cycle.
Preprohypocretin-positive neurons were found in the perifornical nucleus and in the dorsal and lateral hypothalamic areas of rat brain.
Quoted textsource-backed
Preprohypocretin-positive neurons were found in the perifornical nucleus and in the dorsal and lateral hypothalamic areas.
The densest extrahypothalamic projection of preprohypocretin-immunoreactive fibers in rat brain was found in the locus coeruleus.
Quoted textsource-backed
The densest extrahypothalamic projection was found in the locus coeruleus.
Although preprohypocretin-positive neurons represent a restricted group of cells, their projections were widely distributed in the rat brain.
Quoted textsource-backed
Although they represent a restricted group of cells, their projections were widely distributed in the brain.
Preprohypocretin-immunoreactive fibers were observed in multiple rat brain regions including hypothalamus, septal nuclei, bed nucleus of the stria terminalis, paraventricular and reuniens thalamic nuclei, zona incerta, subthalamic nucleus, central gray, substantia nigra, raphe nuclei, parabrachial area, medullary reticular formation, nucleus of the solitary tract, cortical regions, amygdaloid nuclei, and olfactory bulb.
Quoted textsource-backed
Fibers were also seen in the septal nuclei, the bed nucleus of the stria terminalis, the paraventricular and reuniens nuclei of the thalamus, the zona incerta, the subthalamic nucleus, the central gray, the substantia nigra, the raphe nuclei, the parabrachial area, the medullary reticular formation, and the nucleus of the solitary tract. Less prominent projections were found in cortical regions, central and anterior amygdaloid nuclei, and the olfactory bulb.