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First-pass extracted concept

primary cilium

Candidate: concept label1 source documents4 linked claims
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Aliases

primary cilia

Extracted Explainers

What the tool is doing

The review presents the primary cilium as an emerging cellular site potentially central to polycystic disease pathogenesis.

Source 1DOIPubMed

What problem it solves

It helps organize mechanistic thinking about how PKD-associated proteins and epithelial defects might connect to cyst formation.

Source 1DOIPubMed

What it does not solve

The abstract does not establish a complete causal mechanism for cyst formation through the cilium.

Source 1DOIPubMed

Evidence Snippets

a neglected cellular organelle, the primary cilium, has emerged as a potential key player in polycystic disease
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1disease genetics summarysupports2002Source 1DOIPubMed

ADPKD is caused by mutations in either PKD1 or PKD2, whereas PKHD1 is the gene responsible for ARPKD.

Quoted textsource-backed
ADPKD is caused by mutations of either the PKD1 gene on chromosome 16 or the PKD2 gene on chromosome 4. The gene responsible for ARPKD (PKHD1) has recently been identified on chromosome 6.
Claim 2mechanistic summarysupports2002Source 1DOIPubMed

The PKD1 gene product has been found to regulate the cell cycle.

Quoted textsource-backed
the PKD1 gene product has been found to regulate the cell cycle
Claim 3mechanistic summarysupports2002Source 1DOIPubMed

The PKD2 gene product has been identified as an intracellular calcium release channel.

Quoted textsource-backed
the PKD2 gene product has been identified as an intracellular calcium release channel
Claim 4pathogenesis summarysupports2002Source 1DOIPubMed

The primary cilium has emerged as a potential key player in polycystic disease.

Quoted textsource-backed
a neglected cellular organelle, the primary cilium, has emerged as a potential key player in polycystic disease