First-pass extracted concept

primary membranous nephropathy

Candidate: concept label1 source documents4 linked claims

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Evidence Snippets

Is primary membranous nephropathy a complement mediated disease? ... In this review we describe the current knowledge on the function of the complement system in primary MN

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2020Molecular ImmunologyDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1disease associationsupports2020Source 1DOI PubMed

After discovery of PLA2R1 and THSD7A as endogenous antigens, IgG4 antibodies against these proteins are assumed to induce membranous nephropathy in over 85% of patients with primary membranous nephropathy.

Claim 2disease mechanismsupports2020Source 1DOI PubMed

Primary membranous nephropathy is an immune complex mediated disease in which circulating autoantibodies bind podocyte autoantigens and form immune complexes in the glomerular basement membrane.

Claim 3mechanistic rolesupports2020Source 1DOI PubMed

Clinical and experimental evidence indicates that immune deposits in membranous nephropathy activate the complement system.

Claim 4open questionneutral2020Source 1DOI PubMed

The role of complement in the pathogenesis of primary membranous nephropathy remains to be defined in light of PLA2R1 and THSD7A antigen discovery.