Prime editing is named as an advanced CRISPR technology enabling targeted modification relevant to cereal crop traits.
First-pass extracted concept
prime editing
Candidate: concept label7 source documents12 linked claims
Live refresh every 5sNext refresh in 5s
Aliases
PE, prime editing
Extracted Explainers
What the tool is doing
Prime editing is presented as a CRISPR-based method for correcting different types of mutations associated with genetic disorders.
Prime editing is named as an emerging technology that may improve precision and safety in this engineering context.
Prime editing is described as one of the tools enabling programmable DNA integration in plants.
Resources required
What problem it solves
What it does not solve
Evidence Snippets
Recent advances in CRISPR technologies, including Cas9, Cas12, Cas13, base editing, and prime editing, have enabled targeted modification of genes and regulatory elements controlling yield, stress tolerance, and grain nutritional quality in major cereals such as rice, wheat, maize, and barley.
Prime editing has recently gained attention for its promising potential in treating genetic disorders caused by different types of mutations.
This review covers the various editing tools and strategies used for precise gene editing in hemophilia, including approaches such as HDR, NHEJ, base editing, prime editing, ex vivo gene editing in iPSCs, and recent LNP-based CRISPR delivery methods for precise editing.
Emerging technologies-base/prime editing, hybrid nucleases, and rigorous monitoring-promise enhanced precision and safety.
Additionally, genome editing technologies, including CRISPR/Cas9-mediated nonhomologous end joining, base editing, and prime editing, offer variant-specific therapeutic potential.
Prime editing offers remarkable versatility in genome editing, but its efficiency remains a major bottleneck.
CRISPR-Cas systems have enabled programmable DNA integration using tools such as ... prime editing (PE)
Supporting Sources
Linked Claims
Cas9, Cas12, Cas13, base editing, and prime editing have enabled targeted modification of genes and regulatory elements controlling yield, stress tolerance, and grain nutritional quality in rice, wheat, maize, and barley.
Quoted textsource-backed
Recent advances in CRISPR technologies, including Cas9, Cas12, Cas13, base editing, and prime editing, have enabled targeted modification of genes and regulatory elements controlling yield, stress tolerance, and grain nutritional quality in major cereals such as rice, wheat, maize, and barley.
New prime editing strategies have been developed that improve editing efficiency.
Prime editing has promising potential for treating genetic disorders caused by different types of mutations.
The source reviews hemophilia gene-editing strategies including HDR, NHEJ, base editing, prime editing, ex vivo iPSC editing, and LNP-based CRISPR delivery methods.
Quoted textsource-backed
This review covers the various editing tools and strategies used for precise gene editing in hemophilia, including approaches such as HDR, NHEJ, base editing, prime editing, ex vivo gene editing in iPSCs, and recent LNP-based CRISPR delivery methods for precise editing.
Gene editing for hemophilia is presented as an emerging approach that aims to provide a permanent cure by precise correction of the mutated gene or targeted integration of coagulation factor cDNA for stable expression.
Quoted textsource-backed
Gene editing for hemophilia is an emerging approach that aims to provide a permanent cure by editing the mutated gene precisely or targeted integration of coagulation factor cDNA into the host genome for stable expression.
Advances in enhanced prime editor and pegRNA systems could accelerate and simplify development of gene therapies for genetic disorders.
Precise DNA insertion tools in plants support applications including in-locus protein tagging, regulatory element engineering, and multi-gene stacking.
Quoted textsource-backed
These tools are transitioned from theoretical concepts to practical applications, supporting applications like in-locus protein tagging, regulatory element engineering, and multi-gene stacking.
CRISPR-Cas systems have enabled programmable DNA integration in plants using gene targeting, prime editing, and recombinase- or transposase-based platforms.
Quoted textsource-backed
CRISPR-Cas systems have enabled programmable DNA integration using tools such as gene targeting (GT), prime editing (PE), and recombinase- or transposase-based platforms.
Key remaining challenges for hereditary hearing loss gene therapy include expanding the therapeutic window, ensuring long-term safety, and establishing ethical and regulatory frameworks.
Quoted textsource-backed
Despite these advances, challenges remain in expanding the therapeutic window, ensuring long-term safety, and establishing ethical and regulatory frameworks for their use.
Base editing, prime editing, hybrid nucleases, and rigorous monitoring are presented as emerging technologies that may enhance precision and safety.
Quoted textsource-backed
Emerging technologies-base/prime editing, hybrid nucleases, and rigorous monitoring-promise enhanced precision and safety.
Current precise DNA insertion approaches in plants face challenges including inefficient large-fragment insertion, delivery barriers, and regulatory hurdles.
Quoted textsource-backed
Key challenges persist, such as inefficient large-fragment insertion, delivery barriers, and regulatory hurdles.
CRISPR/Cas9-mediated nonhomologous end joining, base editing, and prime editing offer variant-specific therapeutic potential for hereditary hearing loss.
Quoted textsource-backed
Additionally, genome editing technologies, including CRISPR/Cas9-mediated nonhomologous end joining, base editing, and prime editing, offer variant-specific therapeutic potential.