As these systems mature, programmable 3D genome engineering is emerging as a transformative pillar of synthetic biology, complementing sequence-based editing as a core modality for both understanding and ultimately reprogramming genome function.
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programmable 3D genome engineering
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Recent genome engineering developments enable targeted manipulation of 3D chromatin architecture, specifically DNA loops, to illuminate causal links between genome structure and function.
The relationship between chromatin interactions and cellular function remains largely correlative, and causality is unresolved.
Current programmable 3D genome engineering approaches are limited by efficiency, scalability, and specificity.
Programmable 3D genome engineering is emerging as a transformative pillar of synthetic biology that complements sequence-based editing.