First-pass extracted concept

programmed cell death

Candidate: concept label4 source documents5 linked claims

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Aliases

PCD

Extracted Explainers

What the tool is doing

The abstract identifies programmed cell death as a molecular event coordinated by VND transcription factors in xylem development.

Source 1DOI PubMed

Evidence Snippets

VND transcription factors regulate xylem development by orchestrating secondary cell wall biosynthesis and programmed cell death.

Evidence 1Source 1DOI PubMedprovenance

OpenAlex concepts for this review include Programmed cell death.

Evidence 2Source 2DOI PubMedprovenance

The nuclear factor-kappaB (NF-kappaB) transcription factors have emerged as major regulators of programmed cell death (PCD) whether via apoptosis or necrosis.

Evidence 3Source 3DOI PubMedprovenance

Supported directly by the review title: "Programmed Cell Death in Animal Development".

Evidence 4Source 4DOI PubMedprovenance

Supporting Sources

Source 1primary paper2025MEDDOI PubMed

1 evidence snippet 1 linked claim Claim 1

Source 2review2018Cell Death and DifferentiationDOI PubMed

1 evidence snippet 1 linked claim Claim 1

Source 3review2006OncogeneDOI PubMed

1 evidence snippet 2 linked claims Claim 1 Claim 2

Source 4review1997CellDOI PubMed

1 evidence snippet 1 linked claim Claim 1

Linked Claims

Claim 1mechanistic rolesupports2025Source 1DOI PubMed

VND transcription factors orchestrate secondary cell wall biosynthesis and programmed cell death during xylem development.

Quoted textsource-backed

Vascular-related NAC (NAM, ATAF1/2, CUC2) domain (VND) transcription factors regulate xylem development by orchestrating secondary cell wall biosynthesis and programmed cell death.

Claim 2document rolesupports2018Source 2DOI PubMed

The source functions as a consensus nomenclature and mechanistic framing review for cell-death pathways.

Quoted textsource-backed

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Claim 3disease relevancesupports2006Source 3DOI PubMed

Improper regulation of programmed cell death by NF-κB has pathological consequences ranging from neurodegeneration to cancer and may reduce therapy effectiveness.

Quoted textsource-backed

improper regulation of PCD by NF-kappaB can have severe pathologic consequences, ranging from neurodegeneration to cancer, where its activity often precludes effective therapy

Claim 4review scope summarysupports2006Source 3DOI PubMed

NF-κB transcription factors are major regulators of programmed cell death, including apoptosis and necrosis.

Quoted textsource-backed

The nuclear factor-kappaB (NF-kappaB) transcription factors have emerged as major regulators of programmed cell death (PCD) whether via apoptosis or necrosis.

Claim 5review scopesupports1997Source 4DOI PubMed

The review concerns programmed cell death in the context of animal development.