Protein fouling can significantly reduce the filtrate flux, capacity, and virus retention during processing of plasma- or mammalian cell-derived biopharmaceuticals through virus removal filters.
First-pass extracted concept
protein fouling in virus removal filters
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protein fouling
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For a membrane fouled to 90% flux decline, simulations show nanoparticle capture shifts upstream by about 0.4 µm away from the filter exit.
Quoted textsource-backed
Simulations show an upstream shift in the location of nanoparticle capture (away from the filter exit) by about 0.4 µm for the membrane fouled to 90% flux decline.
The upstream shift in nanoparticle capture is attributed to pore constriction from protein deposition, which redistributes flow paths within the membrane.
Quoted textsource-backed
This is due to pore constriction from protein deposition, highlighting how fouling redistributes flow paths within the membrane.
Flow and particle-transport simulations in the protein-fouled membrane agree well with independent experimental measurements of permeability and particle-capture location.
Quoted textsource-backed
Model simulations of flow and particle transport in the protein-fouled membrane are in good agreement with independent experimental measurements of the permeability and location of particle capture.
Protein fouling significantly reduces filtrate flux, capacity, and virus retention in virus removal filtration of plasma- or mammalian cell-derived biopharmaceuticals.
Quoted textsource-backed
Protein fouling can significantly reduce the filtrate flux, capacity, and virus retention during processing of plasma- or mammalian cell-derived biopharmaceuticals through virus removal filters.
After fouling to 90% flux decline, porosity in the size-selective region near the exit of the Viresolve® Pro membrane decreases by approximately 40%.
Quoted textsource-backed
Protein fouling causes a significant reduction in the membrane porosity, which decreases by approximately 40% in the size-selective region near the exit of the highly asymmetric Viresolve® Pro membrane after the filter is fouled to 90% flux decline.
Protein fouling reduces the number of small pores in the Viresolve® Pro membrane by more than a factor of two.
Quoted textsource-backed
There is a corresponding reduction in the number of small pores by more than a factor of two.