First-pass extracted concept

Protein kinase D

Candidate: concept label1 source documents5 linked claims

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Aliases

atypical PKCμ, PKCμ, PKD

Evidence Snippets

Protein kinase D (PKD) ... not only is a direct DAG target but also lies downstream of PKCs in a novel signal transduction pathway implicated in the regulation of multiple fundamental biological processes.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2005Journal of Biological ChemistryDOI PubMed

1 evidence snippet 5 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1activation mechanismsupports2005Source 1DOI PubMed

In intact cells, PKD activation by phorbol esters, cell-permeant DAGs, bryostatin, regulatory peptides, and growth factors is mediated through a PKC-dependent pathway.

Claim 2classificationsupports2005Source 1DOI PubMed

PKD is the founding member of a distinct protein kinase family and is classified within the CAMK group rather than the PKC/AGC group.

Claim 3domain functionsupports2005Source 1DOI PubMed

The PKD cysteine-rich domain mediates high-affinity phorbol ester binding, contributes to stimulus-induced translocation, and represses catalytic activity.

Claim 4domain functionsupports2005Source 1DOI PubMed

The PKD PH domain has an autoregulatory role that helps maintain PKD in an inactive catalytic state.

Claim 5mechanism summarysupports2005Source 1DOI PubMed

PKD functions both as a direct DAG target and as a downstream effector in PKC-dependent signaling pathways.