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proteostasis network

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Evidence Snippets

Protein aggregation is routinely suppressed by the proteostasis network (PN), a collection of macromolecular machines that operate in diverse ways to maintain proteome integrity across subcellular compartments and between tissues to ensure a healthy life span.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2015Annual Review of BiochemistryDOI PubMed

1 evidence snippet 5 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1aging mechanismsupports2015Source 1DOI PubMed

Disease susceptibility may arise from early changes in the composition and activity of the proteostasis network.

Quoted textsource-backed

We explore emerging evidence that disease susceptibility arises from early changes in the composition and activity of the PN.

Claim 2disease associationsupports2015Source 1DOI PubMed

Loss of proteostasis is a common feature of aging and disease and is characterized by nonnative protein aggregates in tissues.

Quoted textsource-backed

Loss of protein homeostasis (proteostasis) is a common feature of aging and disease that is characterized by the appearance of nonnative protein aggregates in various tissues.

Claim 3disease mechanismsupports2015Source 1DOI PubMed

Disruption of the proteostasis network and related stress response pathways contributes to disease initiation and progression.

Quoted textsource-backed

We review the composition, function, and organizational properties of the PN ... and discuss the mechanisms by which disruption of the PN, and related stress response pathways, contributes to the initiation and progression of disease.

Claim 4functional rolesupports2015Source 1DOI PubMed

The proteostasis network suppresses protein aggregation and maintains proteome integrity across subcellular compartments and between tissues.

Quoted textsource-backed

Protein aggregation is routinely suppressed by the proteostasis network (PN), a collection of macromolecular machines that operate in diverse ways to maintain proteome integrity across subcellular compartments and between tissues to ensure a healthy life span.

Claim 5translational outlooksupports2015Source 1DOI PubMed

A more complete understanding of the temporal and spatial properties of the proteostasis network may improve development of treatments for protein conformational diseases.

Quoted textsource-backed

We propose that a more complete understanding of the temporal and spatial properties of the PN will enhance our ability to develop effective treatments for protein conformational diseases.