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First-pass extracted concept

Prox1

Candidate: concept label1 source documents7 linked claims
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Aliases

PROX1

Extracted Explainers

What the tool is doing

In this paper, Prox1 is presented as a tumor-suppressive regulator in breast cancer that suppresses proliferation, migration, and the Warburg effect. The abstract also states that its anti-tumor effect is mediated by direct repression of c-Myc transcription.

Source 1DOIPubMed

What problem it solves

The study suggests Prox1 could be relevant for therapeutic strategies aimed at limiting breast cancer growth and tumor-related metabolism.

Source 1DOIPubMed

What it does not solve

The abstract does not establish a deployable therapeutic platform or delivery strategy for Prox1-based treatment.

Source 1DOIPubMed

Evidence Snippets

we identified Prox1 as a negative regulator of proliferation and tumor-related metabolism in breast cancer
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1cellular effectsupports2023Source 1DOIPubMed

Prox1 over-expression suppresses proliferation, migration, and the Warburg effect in human breast cancer cells without inducing apoptosis.

Claim 2clinical associationsupports2023Source 1DOIPubMed

Breast tumors from human patients exhibited reduced Prox1 expression, and higher Prox1 expression was associated with favorable prognosis in breast cancer patients.

Claim 3functional rolesupports2023Source 1DOIPubMed

Prox1 is a negative regulator of proliferation and tumor-related metabolism in breast cancer.

Claim 4in vivo effectsupports2023Source 1DOIPubMed

Prox1 over-expression inhibits breast tumor growth in heterotopic and orthotopic xenograft mouse models.

Claim 5mechanismsupports2023Source 1DOIPubMed

The anti-tumorigenic effect of Prox1 is mediated by direct repression of c-Myc transcription and its downstream target genes.

Claim 6rescue experimentsupports2023Source 1DOIPubMed

c-Myc over-expression from an artificial promoter not targeted by Prox1 reverses Prox1 anti-tumor effects.

Claim 7therapeutic implicationsupports2023Source 1DOIPubMed

Prox1 is suggested as a promising therapeutic gene for breast cancer.