First-pass extracted concept

PVH Gpr45 neurons

Candidate: concept label1 source documents4 linked claims

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Aliases

Gpr45-expressing neurons in the PVH, PVH^Gpr45 neurons

Evidence Snippets

The Gpr45-CreERT2 knock-in model was used to express chronic and acute actuators to the PVH to assess the role of PVH Gpr45 neurons in energy homeostasis.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2025MEDDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1acute functionsupports2025Source 1DOI PubMed

Acute chemogenetic stimulation of PVH Gpr45 neurons durably suppresses food intake regardless of caloric need state or food palatability.

Claim 2anatomical site of actionsupports2025Source 1DOI PubMed

Targeted deletion of Gpr45 from the PVH phenocopies obesity and hyperphagia, supporting the PVH glutamatergic population as a major site of Gpr45 action.

Claim 3necessity testsupports2025Source 1DOI PubMed

Permanent silencing of PVH Gpr45 neurons with TeNT causes rapid weight gain and increased food intake, supporting a critical role for PVH Gpr45 neuronal activity in body-weight and appetite regulation.

Claim 4sufficiency testmixed2025Source 1DOI PubMed

Constitutive activation of PVH Gpr45 neurons with NaChBac has limited to no effect on body weight and food consumption, implying redundant circuitry may limit weight-loss effects.