First-pass extracted concept

PVN CRH neurons

Candidate: concept label1 source documents6 linked claims

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Aliases

PVN corticotropin-releasing hormone-producing neurons, PVNCRH-producing neurons

Evidence Snippets

In vivo recording revealed a critical circuit from SCN vasoactive intestinal peptide (SCNVIP)-producing neurons to PVN corticotropin-releasing hormone (PVNCRH)-producing neurons.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2021Nature CommunicationsDOI PubMed

1 evidence snippet 6 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1entrainment claimsupports2021Source 1DOI PubMed

Daily SCN VIP activation entrains PVN clock gene rhythms by inhibiting PVN CRH neurons.

Claim 2genetic perturbation effectsupports2021Source 1DOI PubMed

Loss of Bmal1 in CRH neurons causes arrhythmic PVN CRH calcium activity and reduces the amplitude and precision of daily corticosterone release.

Claim 3integrated mechanism claimsupports2021Source 1DOI PubMed

Daily corticosterone release depends on coordinated clock gene rhythms and neuronal activity rhythms in both SCN VIP neurons and PVN CRH neurons.

Claim 4mechanistic circuit claimsupports2021Source 1DOI PubMed

A critical circuit links SCN VIP neurons to PVN CRH neurons.

Claim 5perturbation effectsupports2021Source 1DOI PubMed

Activation of SCN VIP neurons reduces corticosterone release and PVN CRH calcium activity, whereas inactivation increases them.

Claim 6temporal activity claimsupports2021Source 1DOI PubMed

PVN CRH neurons peak in clock gene expression around midday and peak in calcium activity about three hours later.