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PVN-VTA oxytocin circuit

Candidate: concept label1 source documents6 linked claims
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Aliases

PVN-VTA OXT neuron terminals, tactile-oxytocin-dopamine pathway

Evidence Snippets

Chemogenetic and optogenetic activation of PVN-VTA OXT neuron terminals reduced anxiety, increased sociality, and enhanced dopamine (DA) release in the nucleus accumbens (NAc) of animals with PS.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1behavioral rescuesupports2025Source 1DOIPubMed

Postnatal back brushing reversed the negative impact of early tail pinching on emotional and social behaviors in mandarin voles.

Quoted textsource-backed
Using mandarin voles, a highly social species, we showed that postnatal back brushing, a proxy for affiliative tactile stimulation, reversed the negative impact of early tail pinching on emotional and social behaviors.
Claim 2causal circuit manipulationsupports2025Source 1DOIPubMed

Chemogenetic and optogenetic activation of PVN-VTA oxytocin neuron terminals reduced anxiety, increased sociality, and enhanced nucleus accumbens dopamine release in animals exposed to painful stimuli.

Quoted textsource-backed
Chemogenetic and optogenetic activation of PVN-VTA OXT neuron terminals reduced anxiety, increased sociality, and enhanced dopamine (DA) release in the nucleus accumbens (NAc) of animals with PS.
Claim 3circuit activity rescuesupports2025Source 1DOIPubMed

Back brushing reversed early tail pinching-induced reductions in PVN oxytocin neuron activity and VTA activity.

Quoted textsource-backed
Back brushing notably reversed the reduction in activities of oxytocin (OXT) neurons in the paraventricular nucleus (PVN) and activities of the ventral tegmental area (VTA) induced by early tail pinching.
Claim 4loss of function effectsupports2025Source 1DOIPubMed

Inhibition of the PVN-VTA oxytocin circuit produced effects opposite to activation.

Quoted textsource-backed
Conversely, inhibition of this circuit produced opposite effects.
Claim 5molecular rescuesupports2025Source 1DOIPubMed

Brushing reversed painful-stimulus-induced hypermethylation of Drd1, Drd2, and Nr3c1 and broader transcriptomic shifts in the nucleus accumbens.

Quoted textsource-backed
At the molecular level, brushing reversed PS-induced hypermethylation of Drd1, Drd2, and Nr3c1, as well as broader transcriptomic shifts in the NAc.
Claim 6pharmacologic dependencysupports2025Source 1DOIPubMed

The behavioral and dopamine effects of PVN-VTA oxytocin terminal activation depended on oxytocin receptor signaling in the VTA because VTA OXTR antagonism reversed them.

Quoted textsource-backed
These effects were reversed by oxytocin receptor (OXTR) antagonism in the VTA.