First-pass extracted concept

receptor-mediated cation channels

Candidate: concept label1 source documents4 linked claims
Live refresh every 5sNext refresh in 5s

Aliases

RMCC

Extracted Explainers

What the tool is doing

RMCC is the term used in the abstract for Ca2+-permeable cation channels activated by receptors and other pathways.

Source 1DOIPubMed

What problem it solves

The term groups related receptor-evoked Ca2+ influx pathways for molecular investigation.

Source 1DOIPubMed

Evidence Snippets

these cation channels (tentatively termed as receptor-mediated cation channels (RMCC))
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1discovery enabling methodsupports2001Source 1DOIPubMed

Use of genetic information and recombinant expression techniques led to discovery of numerous mammalian TRP homologues that revealed novel receptor-mediated cation channels.

Quoted textsource-backed
Use of the genetic information and recombinant expression technique lead to the discovery of numerous mammalian TRP homologues revealing novel RMCCs.
Claim 2historical mechanistic inferencesupports2001Source 1DOIPubMed

Molecular studies of Drosophila TRP provided an important clue for understanding the molecular mechanisms underlying receptor-mediated cation channels.

Quoted textsource-backed
An important clue to understand the molecular mechanisms underlying these cation channels (tentatively termed as receptor-mediated cation channels (RMCC)) was first provided through molecular studies of the transient receptor potential (trp) protein (TRP)
Claim 3mechanistic rolesupports2001Source 1DOIPubMed

Receptor and related extracellular stimulation activates Ca2+-permeable cation channels that form essential signaling pathways controlling biological responses.

Quoted textsource-backed
Cellular stimulation from the surrounding extracellular environment via receptors and other pathways evoke activation of Ca2+-permeable cation channels that form essential signaling pathways in controlling biological responses.
Claim 4translational potentialsupports2001Source 1DOIPubMed

Recent findings in molecular investigation of receptor-mediated cation channels should provide powerful tools for development of novel pharmaceutical targets.

Quoted textsource-backed
The recent findings should provide powerful tools for the development of novel pharmaceutical targets.