First-pass extracted concept

redox-associated posttranslational protein modifications

Candidate: concept label1 source documents5 linked claims

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Aliases

PTMs

Evidence Snippets

Here, we review the crucial roles of redox-associated posttranslational protein modifications (PTMs) in mitochondrial metabolic regulation.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2020The Plant CellDOI PubMed

1 evidence snippet 5 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1caveatsupports2020Source 1DOI PubMed

Some detected PTM sites may represent molecular noise caused by spurious reactions rather than functional regulation.

Claim 2evidence gapsupports2020Source 1DOI PubMed

Targeted proteomics has generated many candidate PTM-regulated mitochondrial proteins, but the functional importance of only a few PTMs is currently understood.

Claim 3functional rolesupports2020Source 1DOI PubMed

Redox-associated PTMs participate both in repair of stress-induced damage and in adjustment of mitochondrial metabolic functions to environmental variation such as light irradiance or oxygen availability.

Claim 4mechanistic modelsupports2020Source 1DOI PubMed

Different PTMs on the same protein or on different proteins in the same metabolic pathway can interact to fine-tune metabolic regulation.

Claim 5systems level rolesupports2020Source 1DOI PubMed

PTMs form a multidimensional regulatory system that provides speed and flexibility for mitochondrial coordination beyond changes in nuclear gene expression alone.