First-pass extracted concept

regulated cell death

Candidate: concept label1 source documents4 linked claims

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Aliases

RCD

Evidence Snippets

By exceeding critical thresholds or perturbing compartment-specific signaling, ROS can initiate, modulate, or suppress regulated cell death (RCD).

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2025MEDDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1coverage scopesupports2025Source 1DOI PubMed

Nineteen distinct forms of cell death are shaped by reactive oxygen species as triggers, modulators, or inhibitors.

Claim 2crosstalk mechanismsupports2025Source 1DOI PubMed

Reactive oxygen species promote crosstalk between death programs, enabling switches from one mode to another and influencing whether outcomes are inflammatory or non-inflammatory.

Claim 3integrative conclusionsupports2025Source 1DOI PubMed

Across regulated cell death pathways, reactive oxygen species act as both gatekeepers and connectors of diverse death programs.

Claim 4mechanistic scopesupports2025Source 1DOI PubMed

Reactive oxygen species can initiate, modulate, or suppress regulated cell death when they exceed critical thresholds or perturb compartment-specific signaling.