First-pass extracted concept

restricted feeding

Candidate: concept label1 source documents4 linked claims

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Aliases

temporal feeding restriction

Evidence Snippets

Here we show that temporal feeding restriction under light-dark or dark-dark conditions can change the phase of circadian gene expression in peripheral cell types by up to 12 h while leaving the phase of cyclic gene expression in the SCN unaffected.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2000Genes & DevelopmentDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1phase resetting effectsupports2000Source 1DOI PubMed

Restricted feeding can shift the phase of circadian gene expression in peripheral tissues by up to 12 hours while leaving SCN cyclic gene expression phase unaffected.

Claim 2resetting kineticssupports2000Source 1DOI PubMed

Sudden large changes in feeding time reset rhythmic gene expression gradually, consistent with a clock-dependent mechanism.

Claim 3tissue specific resettingsupports2000Source 1DOI PubMed

Food-induced phase resetting occurs faster in liver than in kidney, heart, or pancreas, but after one week of daytime feeding the phases become similar across examined peripheral tissues.

Claim 4uncoupling mechanismsupports2000Source 1DOI PubMed

Metabolic changes induced by feeding can uncouple peripheral circadian oscillators from the central pacemaker in the SCN.