Ongoing efforts to harness rod-shaped virus-like particles for nanomedicine involve a variety of strategies to control assembly, such as genetic changes to coat proteins, RNA scaffold engineering, and physicochemical changes to the solution conditions.
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rod-shaped virus-like particles
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Aliases
rod-shaped VLPs
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Supporting Sources
Linked Claims
The properties of rod-shaped viral particles are useful for controlling biodistribution and cellular interactions for nanoparticle accumulation and targeted delivery in vivo.
Assembly-control strategies enable precise tuning of rod-shaped virus-like particle shape, aspect ratio, and composition.
Controlled assembly of rod-shaped virus-like particles can be pursued through coat-protein genetic changes, RNA scaffold engineering, and physicochemical changes to solution conditions.
Rod-shaped viruses and virus-like particles have directional assembly, uniform size, ease of surface functionalization, and tunable aspect ratio.