Nowadays it has become more clear that, in addition to this acquired immune system, also an innate immune system has been secreted into saliva. In the last years more light has been shed on the protective functions of the peptides and of the (glyco)proteins of the innate immune system, contributing to the first line of oral defence.
First-pass extracted concept
salivary innate immune system
Candidate: concept label1 source documents6 linked claims
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Aliases
first line of oral defence, innate immune system secreted into saliva
Evidence Snippets
Supporting Sources
Linked Claims
Apparent redundancy of salivary defense mechanisms is suggested mainly by in vitro studies, while in vivo inhibitory and killing effects are described as precisely regulated within an ecological equilibrium.
Quoted textsource-backed
Although it appears at first glance on Figure 1 that a redundance to defence mechanisms in saliva is present, this has been suggested only by in vitro studies. In vivo it is clear that the inhibiting and killing effects are regulated precisely so that an ecology exists in an equilibrium system in the oral cavity.
Saliva helps maintain oral microbial steady state, and impaired salivary clearing can shift oral microflora toward Gram-negative species associated with pulmonary complications.
Quoted textsource-backed
Saliva plays a key role in maintaining the steady-state of this system, as becomes clear when the salivary clearing is blocked... within 2 weeks a shift in the oral microflora occurs to Gram-negative species, which subsequently spread into the respiratory tract causing pulmonary afflictions.
Saliva is important for maintaining oral health and protecting against opportunistic infection.
Quoted textsource-backed
It is generally accepted that saliva is of paramount importance for the maintenance of oral health... These include dry mouth feeling (xerostomia), difficulty with swallowing food, and an increased susceptibility for opportunistic infections.
MUC5B is a gel-forming salivary mucin that acts as a barrier protecting epithelium and oral surfaces and modulates microbial colonization.
Quoted textsource-backed
Because of their high carbohydrate content... the classical secretory mucins already at low concentrations form hydrophilic viscoelastic gels. These gels function as barriers, protecting the underlying epithelium... In the oral cavity, MUC5B is present in the protein films (pellicles) covering the enamel and epithelial surfaces, and in this quality protect against acidic attacks and modulate the microbial colonization of these surfaces.
MUC7 and salivary agglutinin are described as major bacteria-agglutinating factors in saliva.
Quoted textsource-backed
It has become clear now that MUC7 and the salivary agglutinin are among the major bacteria-agglutinating factors in saliva.
The review states that saliva contains an innate immune system composed in part of peptides and glycoproteins that contribute to first-line oral defense.
Quoted textsource-backed
Nowadays it has become more clear that, in addition to this acquired immune system, also an innate immune system has been secreted into saliva... the protective functions of the peptides and of the (glyco)proteins of the innate immune system, contributing to the first line of oral defence.