First-pass extracted concept

SARS-CoV-2 cell entry mechanisms

Candidate: concept label1 source documents4 linked claims

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Evidence Snippets

The review title explicitly states the source focuses on mechanisms of SARS-CoV-2 entry into cells.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2021Nature Reviews Molecular Cell BiologyDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1mechanistic summarysupports2021Source 1DOI PubMed

Accessory host factors such as neuropilin-1 are included among mechanisms relevant to SARS-CoV-2 entry in the source-associated evidence scaffold.

Claim 2mechanistic summarysupports2021Source 1DOI PubMed

Furin cleavage of spike is treated as a key component shaping SARS-CoV-2 entry competence in the source-associated evidence scaffold.

Claim 3mechanistic summarysupports2021Source 1DOI PubMed

TMPRSS2-dependent plasma membrane entry and cathepsin-dependent endosomal entry are described as alternative SARS-CoV-2 entry routes in the source-associated evidence scaffold.

Claim 4review scope summarysupports2021Source 1DOI PubMed

This review synthesizes mechanisms of SARS-CoV-2 entry into cells, centering receptor usage, protease-dependent spike activation, and alternative entry routes.