Here, we review how the messages are transferred from the first messenger (the ligand) to the receptor, and then decoded with the help of cascades of second messengers (kinases, phosphatases, GTPases, ions, and small molecules such as cAMP, cGMP, diacylglycerol, etc.).
First-pass extracted concept
second messenger system
Candidate: concept label2 source documents3 linked claims
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Aliases
second messengers
Evidence Snippets
The review title explicitly frames inositol trisphosphate and diacylglycerol as second messengers.
Supporting Sources
Linked Claims
Cellular messages are transferred from ligands to receptors and decoded through cascades of second messengers including kinases, phosphatases, GTPases, ions, and small molecules such as cAMP, cGMP, and diacylglycerol.
Quoted textsource-backed
Here, we review how the messages are transferred from the first messenger (the ligand) to the receptor, and then decoded with the help of cascades of second messengers (kinases, phosphatases, GTPases, ions, and small molecules such as cAMP, cGMP, diacylglycerol, etc.).
Specificity of ligand response profiles is generated by combinations of selected intracellular signaling intermediates despite a limited number of intracellular messengers.
Quoted textsource-backed
Although there are limited numbers of intracellular messengers, the specificity of the response profiles to the ligands is generated by the involvement of a combination of selected intracellular signaling intermediates.
The source reviews inositol trisphosphate and diacylglycerol as second messengers.