First-pass extracted concept

selective autophagy

Candidate: concept label2 source documents3 linked claims

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Evidence Snippets

This review describes selective and secretory autophagy and their role in drusen biogenesis, senescence-associated secretory phenotype, inflammation and epithelial-mesenchymal transition in the pathogenesis of AMD.

Evidence 1Source 1DOI PubMedprovenance

The review title explicitly names selective autophagy.

Evidence 2Source 2DOI PubMedprovenance

Supporting Sources

Source 1review2022AutophagyDOI PubMed

1 evidence snippet 2 linked claims Claim 1 Claim 2

Source 2review2018Neurobiology of DiseaseDOI PubMed

1 evidence snippet 1 linked claim Claim 1

Linked Claims

Claim 1pathogenesis rolesupports2022Source 1DOI PubMed

The review describes selective and secretory autophagy as being involved in drusen biogenesis, senescence-associated secretory phenotype, inflammation, and epithelial-mesenchymal transition in age-related macular degeneration.

Claim 2review scope statementsupports2022Source 1DOI PubMed

Macroautophagy/autophagy is an emerging factor in age-related macular degeneration pathology.

Claim 3review scope summarysupports2018Source 2DOI PubMed

The review centers on selective autophagy receptors and neurodegeneration-linked receptors including SQSTM1/p62 and OPTN.