self-assembling protein nanocages

Rational design of self-assembling protein nanocages has promise for synthetic biology, biotechnology, and biomedical applications.

Protein cages can be designed in diverse architectures and sizes, and their assembly and disassembly can be regulated by chemical, biological, and physical signals.

De novo protein cage design has recently been revolutionized by modular protein design, computational design of interacting surfaces, and machine learning-based generative protein design.

Protein nanocage cavities can be tailored to encapsulate and protect cargo molecules such as drugs, enzymes, or imaging agents.

Protein nanocages are nanoparticles with an inner cavity formed by self-assembly of repetitive protein building blocks.