First-pass extracted concept

serotonin

Candidate: concept label2 source documents7 linked claims

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Aliases

5-HT, 5-hydroxytryptamine

Evidence Snippets

Here, we review the roles of the monoamines dopamine (DA), norepinephrine (NE), serotonin (5-HT), and other neuromodulators in controlling the activity of the ACC.

Evidence 1Source 1DOI PubMedprovenance

Serotonin (5-hydroxytryptamine, 5-HT) is acknowledged as a major neuromodulator of nervous systems in both invertebrates and vertebrates.

Evidence 2Source 2DOI PubMedprovenance

Supporting Sources

Source 1primary paper2023MEDDOI PubMed

1 evidence snippet 2 linked claims Claim 1 Claim 2

Source 2review2020International Journal of Molecular SciencesDOI PubMed

1 evidence snippet 5 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1disease mechanismsupports2023Source 1DOI PubMed

Chronic pain alters neuromodulator signaling in anterior cingulate cortex circuits to promote pathological hyperexcitability.

Quoted textsource-backed

how chronic pain alters their signaling in ACC circuits to promote pathological hyperexcitability

Claim 2mechanistic rolesupports2023Source 1DOI PubMed

Dopamine, norepinephrine, serotonin, and other neuromodulators control activity of the anterior cingulate cortex.

Quoted textsource-backed

we review the roles of the monoamines dopamine (DA), norepinephrine (NE), serotonin (5-HT), and other neuromodulators in controlling the activity of the ACC

Claim 3adaptation summarysupports2020Source 2DOI PubMed

Serotonin is presented as a prototypical neuromodulator fundamentally involved in organismal adaptation across the animal kingdom.

Quoted textsource-backed

5-HT is, therefore, the prototypical neuromodulator fundamentally involved in the adaptation of all organisms across the animal kingdom.

Claim 4behavioral scope summarysupports2020Source 2DOI PubMed

The review summarizes serotonin involvement across motor activity, arousal, sleep and circadian rhythm, feeding, social interactions and aggressiveness, anxiety, mood, learning and memory, impulsive-compulsive dimensions, and behavioral flexibility.

Quoted textsource-backed

In particular, we focus on the motor activity, arousal, sleep and circadian rhythm, feeding, social interactions and aggressiveness, anxiety, mood, learning and memory, or impulsive/compulsive dimension and behavioral flexibility.

Claim 5evolutionary conservation summarysupports2020Source 2DOI PubMed

Despite distinct organization of serotonin systems across the animal kingdom, serotonin influences on behavior and cognition appear evolutionarily conserved.

Quoted textsource-backed

In spite of a completely distinct organization of the 5-HT systems across the animal kingdom, several lines of evidence suggest that the influences of 5-HT on behavior and cognition are evolutionary conserved.

Claim 6functional role summarysupports2020Source 2DOI PubMed

Serotonin is a major neuromodulator in nervous systems of both invertebrates and vertebrates.

Quoted textsource-backed

Serotonin (5-hydroxytryptamine, 5-HT) is acknowledged as a major neuromodulator of nervous systems in both invertebrates and vertebrates.

Claim 7mechanistic role summarysupports2020Source 2DOI PubMed

Serotonin more often fine-tunes neuronal responses underlying behavior than directly triggers or halts specific behaviors.

Quoted textsource-backed

The roles of 5-HT, illustrated in both invertebrates and vertebrates, show that it is more able to potentiate or mitigate the neuronal responses necessary for the fine-tuning of most behaviors, rather than to trigger or halt a specific behavior.