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Shank3B mutant mouse model

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Aliases

Shank3B mutant mice, Shank3B mutant mouse model of autism

Evidence Snippets

Here, we utilized the Shank3B mutant mouse model of autism

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2017Journal of Clinical InvestigationDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1behavioral rescuesupports2017Source 1DOI PubMed

Enhancing striatopallidal medium spiny neuron activity with hM3Dq DREADD rescued repetitive grooming behavior in Shank3B mutant mice.

Quoted textsource-backed

the repetitive grooming behavior was rescued by selectively enhancing the striatopallidal MSN activity via a Gq-coupled human M3 muscarinic receptor (hM3Dq)

Claim 2causal interpretationsupports2017Source 1DOI PubMed

Indirect striatal pathway disruption might play a causative role in repetitive behavior in the Shank3B mutant mouse model.

Quoted textsource-backed

indicate that the indirect striatal pathway disruption might play a causative role in repetitive behavior of Shank3B mutant mice

Claim 3differential pathway effectsupports2017Source 1DOI PubMed

In the Shank3B mutant mouse model, Shank3 deletion preferentially affects synapses onto striatopallidal medium spiny neurons.

Quoted textsource-backed

We found that Shank3 deletion preferentially affects synapses onto striatopallidal MSNs.

Claim 4phenotype descriptionsupports2017Source 1DOI PubMed

Striatopallidal medium spiny neurons in Shank3B mutant mice show defects in synaptic transmission, synaptic plasticity, and spine density.

Quoted textsource-backed

Striatopallidal MSNs showed profound defects, including alterations in synaptic transmission, synaptic plasticity, and spine density.