First-pass extracted concept

shear-dependent mass transfer mechanism for atherogenesis

Candidate: concept label1 source documents9 linked claims

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Aliases

shear dependent mass transport phenomena

Extracted Explainers

What the tool is doing

This paper proposes that arterial wall shear influences atheroma development by altering diffusional mass transport between the arterial wall and flowing blood. The mechanism is framed especially around cholesterol movement.

Source 1DOI PubMed

What problem it solves

It is offered to explain why early atheroma localizes to low-shear regions rather than supporting a direct wall-damage hypothesis from blood motion.

Source 1DOI PubMed

What it does not solve

The abstract does not provide definitive wall-phase transport measurements, so the mechanism remains partly conjectural in that respect.

Source 1DOI PubMed

Alternatives

The paper explicitly contrasts this proposal with prior suggestions that atheroma is caused by wall damage due to the motion of blood.

Source 1DOI PubMed

Evidence Snippets

Instead it immediately suggests that the process is associated with shear dependent mass transport phenomena.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper1971Proceedings of the Royal Society of London. Series B, Biological sciencesDOI PubMed

1 evidence snippet 9 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1correlationsupports1971Source 1DOI PubMed

Early atheroma in humans is spatially coincident with arterial regions where wall shear rate is expected to be relatively low, whereas lesion development is inhibited or retarded in regions where wall shear rate is expected to be relatively high.

Claim 2mechanismsupports1971Source 1DOI PubMed

Cholesterol accumulates in low shear regions because local diffusional efflux from wall to blood is inhibited by a reduced concentration gradient.

Claim 3mechanismsupports1971Source 1DOI PubMed

Shear enhances mass transport by steepening the concentration gradient so that diffusion from the arterial wall is promoted when diffused material is swept away rapidly.

Claim 4mechanistic importancesupports1971Source 1DOI PubMed

Wall shear rate may be a major controlling factor in the development of atheroma, and high shear may retard progression of the process.

Claim 5mechanistic interpretationsupports1971Source 1DOI PubMed

The observed correlation between low wall shear and early atheroma is inconsistent with a wall-damage-by-blood-motion explanation and instead suggests a shear-dependent mass transport mechanism.

Claim 6mechanistic model constraintsupports1971Source 1DOI PubMed

The influence of shear on diffusion between arterial wall and blood depends on the relative resistances of wall-phase and blood-phase diffusion, and diffusion is not appreciably shear dependent if blood-phase resistance is small compared with wall-phase resistance.

Claim 7model rejectionsupports1971Source 1DOI PubMed

A net flux of cholesterol from blood to wall cannot account for the observed quasi-steady-state distribution of atheromatous lesions because mass transport is inhibited in low shear regions by the thick diffusional boundary layer.

Claim 8negative mechanistic inferencesupports1971Source 1DOI PubMed

The reported correlations provide no support for platelet involvement in the development of early atheroma.

Claim 9scope claimsupports1971Source 1DOI PubMed

The proposed theoretical schemes may unify naturally occurring and experimentally induced atheroma.