First-pass extracted concept

simple and complex haploinsufficiency analysis

Candidate: concept label1 source documents4 linked claims

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Aliases

CHI analyses, simple and complex haploinsufficiency

Evidence Snippets

The role of these TFs was dissected using simple and complex haploinsufficiency (CHI) analyses to examine the impact of gene dosage on cell fate.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2025MEDDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1gene dosage effectsupports2025Source 1DOI PubMed

Simple and complex haploinsufficiency analyses were used to examine how transcription factor gene dosage affects white-opaque cell fate in Candida albicans.

Claim 2gene dosage sensitivitysupports2025Source 1DOI PubMed

Among single heterozygotes, loss of one allele of WOR1 had the greatest impact on white-opaque switching.

Claim 3genetic interactionsupports2025Source 1DOI PubMed

Complex haploinsufficiency analysis revealed strong genetic interactions between core transcription factors including WOR3 and WOR4.

Claim 4mechanistic linksupports2025Source 1DOI PubMed

Changes to transcription factor gene dosage and valency can alter cell fate determination, and these changes are linked to propensity for condensate formation.