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single-cell transcriptomics

Candidate: concept label2 source documents3 linked claims
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Aliases

single-cell RNA sequencing

Extracted Explainers

What the tool is doing

Single-cell transcriptomics is used here to define neuronal and neural-progenitor-like glioblastoma cell states.

Source 2DOIPubMed

Resources required

The abstract supports a requirement for single-cell molecular profiling, but gives no protocol details.

Source 2DOIPubMed

What problem it solves

It provides molecular resolution for linking glioblastoma heterogeneity to invasive behavior.

Source 2DOIPubMed

What it does not solve

The abstract does not indicate that transcriptomics alone captures the functional neuronal input or calcium signaling phenotypes.

Source 2DOIPubMed

Alternatives

The abstract pairs molecular single-cell data with functional single-cell data rather than presenting transcriptomics as a standalone solution.

Source 2DOIPubMed

Evidence Snippets

Over the past several years, single-cell and spatial transcriptomics have yielded unprecedented insights into cellular, tissue, and organ physiology.
Evidence 1Source 1DOIPubMedprovenance
This subpopulation corresponds to neuronal and neural-progenitor-like tumor cell states, as defined by single-cell transcriptomics, both in mouse models and in the human disease.
Evidence 2Source 2DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1application capabilitysupports2026Source 1DOIPubMed

Single-cell and spatial transcriptomics have yielded unprecedented insights into cellular, tissue, and organ physiology.

Claim 2integrative conclusionsupports2022Source 2DOIPubMed

Superimposed molecular and functional single-cell data reveal that neuronal mechanisms govern glioblastoma cell invasion on multiple levels.

Quoted textsource-backed
Collectively, superimposing molecular and functional single-cell data revealed that neuronal mechanisms govern glioblastoma cell invasion on multiple levels.
Claim 3state mappingsupports2022Source 2DOIPubMed

The invasive synaptically connected glioblastoma subpopulation corresponds to neuronal and neural-progenitor-like tumor cell states defined by single-cell transcriptomics.

Quoted textsource-backed
This subpopulation corresponds to neuronal and neural-progenitor-like tumor cell states, as defined by single-cell transcriptomics, both in mouse models and in the human disease.