First-pass extracted concept

site-specific epigenetic editing

Candidate: concept label1 source documents4 linked claims

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Extracted Explainers

What the tool is doing

This concept refers to tools that enable targeted editing of epigenetic states at specific genomic sites.

Source 1DOI PubMed

What problem it solves

It addresses the prior lack of selective epigenome manipulation with genetic, cellular, and temporal precision.

Source 1DOI PubMed

Alternatives

The abstract does not name alternative tool classes, but contrasts these emerging tools with the prior lack of selective manipulation methods.

Source 1DOI PubMed

Evidence Snippets

In addition to allowing site-specific epigenetic editing, these tools can be paired with optogenetic approaches to provide temporal control over epigenetic processes.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2014Dialogues in Clinical NeuroscienceDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1capability statementsupports2014Source 1DOI PubMed

An emerging suite of tools enables robust yet selective interrogation of the epigenome.

Quoted textsource-backed

This review highlights an emerging suite of tools that enable robust yet selective interrogation of the epigenome.

Claim 2capability statementsupports2014Source 1DOI PubMed

Site-specific epigenetic editing tools can be paired with optogenetic approaches to provide temporal control over epigenetic processes.

Quoted textsource-backed

In addition to allowing site-specific epigenetic editing, these tools can be paired with optogenetic approaches to provide temporal control over epigenetic processes

Claim 3impact statementsupports2014Source 1DOI PubMed

Improved control over epigenetic modifications promises to improve understanding of epigenetic modifications in human health and disease states.

Quoted textsource-backed

This improved control promises to revolutionize our understanding of epigenetic modifications in human health and disease states.

Claim 4problem statementsupports2014Source 1DOI PubMed

Understanding of epigenetic mechanisms has been limited by the lack of tools that selectively manipulate the epigenome with genetic, cellular, and temporal precision.

Quoted textsource-backed

Until recently our understanding of epigenetic mechanisms has been limited by the lack of tools that can selectively manipulate the epigenome with genetic, cellular, and temporal precision