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SK1-associated autophagy

Candidate: concept label1 source documents5 linked claims
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Aliases

sphingosine kinase 1-associated autophagy

Evidence Snippets

We investigated if sphingosine kinase 1 (SK1)-associated autophagy differs between two symbiotic brain cell types-neurons and astrocytes.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1cell type differencesupports2018Source 1DOIPubMed

SK1-associated autophagy differs between neurons and astrocytes.

Claim 2differential responsesupports2018Source 1DOIPubMed

Benzoxazine autophagy inducers upregulate SK1 and neuroprotective autophagy in neurons but not in astrocytes.

Claim 3differential responsesupports2018Source 1DOIPubMed

Starvation enhances SK1-associated autophagy in astrocytes but not in neurons.

Claim 4functional effectsupports2018Source 1DOIPubMed

In astrocytes, SK1 is cytoprotective and promotes degradation of mutant huntingtin.

Claim 5toxicity effectsupports2018Source 1DOIPubMed

Overexpressed SK1 is toxic to neurons, and the toxicity localizes to the neuronal soma.