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sleep deprivation

Candidate: concept label2 source documents7 linked claims
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Aliases

SD

Evidence Snippets

Sleep deprivation (SD) disturbs the circadian physiology and exerts a negative impact on brain and behavioural functions.
Evidence 1Source 1DOIPubMedprovenance
One intervention that rapidly alleviates depressive symptoms is sleep deprivation
Evidence 2Source 2DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1disease association summarysupports2020Source 1DOIPubMed

The proteins and pathways negatively affected by sleep deprivation are implicated in neurological disorders including Alzheimer's disease and Parkinson's disease.

Claim 2mechanistic summarysupports2020Source 1DOIPubMed

Sleep deprivation affects the glymphatic system, a glial-dependent metabolic waste clearance pathway, and is associated with accumulation of misfolded proteins in synaptic compartments and cognitive decline.

Claim 3mechanistic summarysupports2020Source 1DOIPubMed

Sleep deprivation impairs cellular clearance of misfolded neurotoxic proteins including alpha-synuclein, amyloid-beta, and tau.

Claim 4pathophysiology summarysupports2020Source 1DOIPubMed

Sleep deprivation affects immunological and redox systems, resulting in neuroinflammation and oxidative stress.

Claim 5mechanistic insightsupports2013Source 2DOIPubMed

The study provides mechanistic insight that sleep deprivation impacts mood through glial signaling involving adenosine A1 receptors.

Claim 6mechanistic requirementsupports2013Source 2DOIPubMed

Astrocytic signaling to adenosine A1 receptors is required for the reduction of depressive-like behaviors following 12 hours of sleep deprivation.

Claim 7phenocopysupports2013Source 2DOIPubMed

Administration of the A1 agonist CCPA mimicked the effect of sleep deprivation on depression phenotypes.