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sleep fragmentation

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Evidence Snippets

We tested the hypothesis that sleep fragmentation is associated with incident Alzheimer's disease (AD) and the rate of cognitive decline in older adults.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1associationsupports2013Source 1DOIPubMed

Greater sleep fragmentation was associated with a faster annual rate of cognitive decline in older adults.

Quoted textsource-backed
In a linear mixed effect analysis, a 0.01 unit increase in sleep fragmentation was associated with a 22% increase in the annual rate of cognitive decline relative to the average rate of decline in the cohort (Estimate = -0.016, SE = 0.007, P = 0.03).
Claim 2associationsupports2013Source 1DOIPubMed

Higher sleep fragmentation was associated with increased risk of incident Alzheimer's disease in older adults.

Quoted textsource-backed
Over a follow-up period of up to 6 years (mean 3.3 years), 97 individuals developed AD. In a Cox proportional hazards model controlling for age, sex, and education, a higher level of sleep fragmentation was associated with an increased risk of AD (HR = 1.22, 95%CI 1.03-1.44, P = 0.02 per 1SD increase in sleep fragmentation).
Claim 3associationsupports2013Source 1DOIPubMed

High sleep fragmentation was associated with approximately 1.5-fold higher risk of developing Alzheimer's disease compared with low sleep fragmentation.

Quoted textsource-backed
An individual with high sleep fragmentation (90th percentile) had a 1.5-fold risk of developing AD as compared with someone with low sleep fragmentation (10th percentile).
Claim 4robustnesssupports2013Source 1DOIPubMed

The association between sleep fragmentation and incident Alzheimer's disease did not vary by demographic lines and remained after adjustment for total daily rest time, chronic medical conditions, and common medications affecting sleep.

Quoted textsource-backed
The association of sleep fragmentation with incident AD did not vary along demographic lines and was unchanged after controlling for potential confounders including total daily rest time, chronic medical conditions, and the use of common medications which can affect sleep.