First-pass extracted concept

small leucine-rich proteoglycan family

Candidate: concept label1 source documents4 linked claims

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Aliases

SLRP, SLRP gene family

Evidence Snippets

This minireview describes recent advances in the biology of the small leucine-rich proteoglycan (SLRP) gene family with special emphasis on the biology of the archetype proteoglycan decorin.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review1999Journal of Biological ChemistryDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1classificationsupports1999Source 1DOI PubMed

Three classes of SLRPs can be identified based on evolutionary conservation, N-terminal cysteine-rich clusters, leucine-rich repeat number, and genomic organization.

Claim 2mechanism summarysupports1999Source 1DOI PubMed

Several SLRPs bind fibrillar collagens and inhibit fibril formation in vitro, affecting assembly kinetics and final fibril diameter.

Claim 3review summarysupports1999Source 1DOI PubMed

The SLRP gene family comprises at least nine structurally related members that have evolved distinct functions and structural specializations.

Claim 4structure functionsupports1999Source 1DOI PubMed

Leucine-rich repeats function as structural modules for molecular recognition and help explain strong protein-protein interactions in SLRPs.