First-pass extracted concept

small molecule-inducible gene expression systems in mESCs

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Evidence Snippets

Here, we characterize three small molecule- and two cell contact-inducible systems for gene expression in and differentiation of mESCs.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2025MEDDOI PubMed

1 evidence snippet 5 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1application capabilitysupports2025Source 1DOI PubMed

These inducible systems can drive direct differentiation of mouse embryonic stem cells into neurons.

Claim 2characterization scopesupports2025Source 1DOI PubMed

The paper characterizes three small molecule-inducible and two cell contact-inducible systems for gene expression in and differentiation of mouse embryonic stem cells.

Claim 3composabilitysupports2025Source 1DOI PubMed

Each inducible system can be used on its own or in combination.

Claim 4context dependencesupports2025Source 1DOI PubMed

The inducible systems function differently across model differentiations.

Claim 5performance statementsupports2025Source 1DOI PubMed

Small molecule- and cell contact-inducible systems work reliably and efficiently for controlling expression of arbitrary genetic payloads in mESCs.