First-pass extracted concept

small tumor-derived extracellular vesicles

Candidate: concept label1 source documents7 linked claims

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Aliases

sTDEVs, TDEVs

Evidence Snippets

we investigate the proteomic and functional alterations of sTDEVs released from F98 glioma and LL/2 Lewis lung carcinoma cells following H-FIRE ablation

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2025MEDDOI PubMed

1 evidence snippet 7 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1functional effectsupports2025Source 1DOI PubMed

sTDEVs derived from ablative H-FIRE doses are capable of disrupting the blood-brain barrier in an in vitro model.

Claim 2immune associationsupports2025Source 1DOI PubMed

In healthy Fischer rats, disruptive sTDEVs are associated with increased recruitment of Iba1-positive immune cells.

Claim 3mechanistic effectsupports2025Source 1DOI PubMed

H-FIRE alters the composition and functionality of small tumor-derived extracellular vesicles released from tumor cells.

Claim 4negative functional resultcontradicts2025Source 1DOI PubMed

Despite altered protein composition, disruptive sTDEVs do not directly increase blood-brain barrier permeability in vivo.

Claim 5pathway associationsupports2025Source 1DOI PubMed

Proteomic changes in H-FIRE-associated TDEVs involve integrin signaling, PDGFR signaling, and ubiquitination pathways.

Claim 6proteomic observationsupports2025Source 1DOI PubMed

sTDEVs derived from ablative doses of H-FIRE contained 108 unique proteins.

Claim 7tropism changesupports2025Source 1DOI PubMed

Disruptive sTDEVs show enhanced tropism for cerebral endothelial cells in vitro and in vivo and persist in the brain longer than sTDEVs released after non-ablative H-FIRE doses.