This review-level concept refers to cortical inhibitory interneurons defined by somatostatin expression. The abstract frames them as a heterogeneous set of functional subclasses with distinct circuit roles.
First-pass extracted concept
somatostatin-expressing inhibitory interneurons
Candidate: concept label1 source documents8 linked claims
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Aliases
somatostatin-expressing interneurons, SOM inhibitory interneurons, SOM neurons
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Linked Claims
Different classes of SOM cells participate in distinct disinhibitory circuits with different inhibitory partners and in different cortical layers.
Quoted textsource-backed
Different classes of SOM cells participate in distinct disinhibitory circuits with different inhibitory partners and in different cortical layers.
Through disinhibitory circuits, SOM cells help encode the behavioral relevance of sensory stimuli by regulating cortical neuron activity based on subcortical and intracortical modulatory input.
Quoted textsource-backed
Through these disinhibitory circuits, SOM cells help encode the behavioral relevance of sensory stimuli by regulating the activity of cortical neurons based on subcortical and intracortical modulatory input.
Several SOM neuron classes show facilitating synapses, specific axonal projections, intralaminar input, and top-down modulation, suggesting distinct computational roles.
Quoted textsource-backed
Several of these classes of SOM neurons show unique dynamics and characteristics, such as facilitating synapses, specific axonal projections, intralaminar input, and top-down modulation, which suggest possible computational roles.
Somatostatin-expressing cortical inhibitory interneurons comprise multiple subpopulations distinguishable by morphology, connectivity, laminar location, firing properties, and molecular marker expression.
Quoted textsource-backed
SOM neurons also comprise a number of subpopulations that can be distinguished by their morphology, input and output connectivity, laminar location, firing properties, and expression of molecular markers.
Optogenetic manipulation of SOM cells has been used to study functional effects on learning and memory, task performance, and integration of cortical activity.
Quoted textsource-backed
The functional effects of such modulation have been studied with optogenetic manipulation of SOM cells, which produces effects on learning and memory, task performance, and the integration of cortical activity.
Despite heterogeneity and variability across cortical areas, current evidence indicates that SOM neurons perform unique neural computations and form functional as well as molecular subclasses of cortical inhibitory interneurons.
Quoted textsource-backed
Thus despite their heterogeneity and variability across cortical areas, current evidence shows that SOM neurons perform unique neural computations, forming not only distinct molecular but also functional subclasses of cortical inhibitory interneurons.
Associative learning leads to long-term changes in SOM-cell connectivity with other neurons, often affecting the strength of inhibitory input they receive.
Quoted textsource-backed
Associative learning leads to long-term changes in the strength of connectivity of SOM cells with other neurons, often influencing the strength of inhibitory input they receive.
SOM cells can be differentially modulated by behavioral state depending on class, sensory system, and behavioral paradigm.
Quoted textsource-backed
SOM cells can be differentially modulated by behavioral state depending on their class, sensory system, and behavioral paradigm.