Using a tunable light-inducible gene expression system, we generate long-range Shh gradients that pattern neural progenitors into spatially distinct progenitor domains mimicking the spatial arrangement of neural progenitors found in vivo during vertebrate neural tube development.
First-pass extracted concept
Sonic hedgehog gradient patterning of neural progenitors
Candidate: concept label1 source documents4 linked claims
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Aliases
morphogen patterning, Shh gradients
Evidence Snippets
Supporting Sources
Linked Claims
The level and duration of morphogen exposure govern the acquisition and maintenance of cell fates.
Quoted textsource-backed
we probe how the level and duration of morphogen exposure govern the acquisition and maintenance of cell fates
A tunable light-inducible gene expression system generates long-range Shh gradients that pattern neural progenitors into spatially distinct progenitor domains resembling vertebrate neural tube organization in vivo.
Quoted textsource-backed
Using a tunable light-inducible gene expression system, we generate long-range Shh gradients that pattern neural progenitors into spatially distinct progenitor domains mimicking the spatial arrangement of neural progenitors found in vivo during vertebrate neural tube development.
Shh has an extracellular half-life of about 1 hour in the reported tissue clearance measurements.
Quoted textsource-backed
We measure tissue clearance rates, revealing that Shh has an extracellular half-life of about 1h
Shh turnover is substantially faster than downstream gene expression dynamics, indicating continual gradient renewal during patterning.
Quoted textsource-backed
The rate of Shh turnover is substantially faster than the downstream gene expression dynamics, indicating that the gradient is continually renewed during patterning.