Sonogenetics is described as using genetic engineering to achieve precise neuronal activation.
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sonogenetics
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What the tool is doing
Sonogenetics is presented as a genetic neuromodulation method for modulating neuronal activity. The abstract states that it has demonstrated high specificity and temporal precision in targeting neuronal populations.
Sonogenetics is identified as a rising area within ultrasound-based regulation of the nervous system.
Sonogenetics is named as a burgeoning research area related to low-intensity focused ultrasound neuromodulation. The abstract presents it as promising but does not provide operational details.
Sonogenetics uses genetic engineering to make target cells express ultrasound-sensitive proteins so that ultrasound can trigger cellular activities and functions. The abstract frames it as a noninvasive cellular manipulation approach.
Sonogenetics combines ultrasound with genetic editing to modulate cellular activity. The abstract describes activation of introduced mechanosensitive membrane channels by ultrasound.
Sonogenetics is named as a tool area that could benefit from the mechanistic findings in this paper.
Sonogenetics uses genetically encoded ultrasound-responsive mediators to control neural activity noninvasively and selectively.
Sonogenetics is described as using ultrasound to non-invasively and precisely control cellular function. The abstract also frames it as useful for modulating and visualizing cellular and molecular processes.
Sonogenetics combines ultrasonic neuromodulation with mechanosensitive channel protein. The abstract presents it as an approach intended to improve the precision and spatial resolution of UNM.
Sonogenetics is described as one of the recent technologies used to perturb whole-organism neuronal function in C. elegans. The abstract groups it with methods that allow interrogation of neural circuits and behavior.
Sonogenetics is named as a newer technique being developed and framed as a future possibility for Parkinson's disease treatment.
The title presents sonogenetics as an approach for activating neurons in C. elegans. It is framed as non-invasive.
Resources required
The abstract indicates that genetic engineering is required.
The approach requires target cells, genetic engineering to introduce ultrasound-sensitive proteins, and ultrasound stimulation. The abstract also implies dependence on appropriate ultrasound properties.
The method requires mechanosensitive channels to be introduced into target cells using gene delivery vectors, followed by ultrasound stimulation.
It requires genetic encoding of ultrasound-responsive mediators and ultrasound stimulation, with in vivo performance evaluation.
The abstract states that sonogenetics includes development of mechano-sensitive proteins, methods to introduce their genes into specific cells, targeted stimulation, and readout of outcomes.
The abstract explicitly states that sonogenetics combines UNM and mechanosensitive channel protein.
The available evidence supports that the approach involves ultrasound stimulation, but the payload does not include the paper abstract or methods needed to specify the full setup.
What problem it solves
It supports precise control of neuronal activation for neuromodulation.
It aims to provide non-surgical and more spatially selective control of cells than traditional ultrasound modalities alone. The review highlights potential use in disease treatment and research applications.
It aims to provide precise, non-invasive regulation of specific cells.
The paper suggests that explaining how ultrasound excites neurons can support further development of sonogenetics.
It offers a way to study neural circuits through noninvasive and selective neural control.
It is presented as a way to stimulate cells, including neurons in deep brain areas, without the surgical light-delivery requirements of optogenetics.
It is presented as a valuable improvement over standard UNM because it may increase precision and spatial resolution and improve specificity.
It contributes a perturbation modality for studying functional connectomics.
It addresses the need for non-invasive neuronal activation in C. elegans.
What it does not solve
The abstract does not establish a single validated actuator, protocol, or disease-specific solution, and it does not specify performance limits. It also does not resolve how broadly the approach works across applications.
The abstract indicates that optimization is still needed and that core in vivo performance properties and safety are not yet fully established.
The abstract notes that little information about sonogenetics is currently available.
The provided evidence does not establish whether it generalizes beyond the reported organism or what limitations apply across cell types or conditions.
Alternatives
The abstract explicitly contrasts sonogenetics with optogenetics, electrogenetics, and magnetogenetics, and also with traditional ultrasound modalities.
The abstract explicitly contrasts sonogenetics with optogenetics, noting that optogenetics needs surgical operations to convey light sources to targeted cells.
The abstract positions sonogenetics as an improvement over UNM alone.
The abstract mentions whole brain imaging, optogenetics, and mutant analysis as related approaches.
The abstract lists optogenetics and magnetogenetics alongside sonogenetics.
OpenAlex concepts mention optogenetics as a nearby topic, but the source-backed title evidence here does not explicitly compare the two methods.
Evidence Snippets
Optogenetics and sonogenetics use genetic engineering to achieve precise neuronal activation
To overcome these challenges, ultrasound control systems based on synthetic biology have been developed, especially for sonogenetics and gas vesicles.
Genetic methods, such as sonogenetics and magnetogenetics, have demonstrated high specificity and temporal precision in targeting neuronal populations
with recent basic science applications of sonogenetics and targeted drug delivery through the BBB
this review discusses the potential and challenges these techniques pose for future research and describes the current state of research on sonogenetics and odourgenetics developed based on optogenetics and chemogenetics.
This new strategy integrates bacterial therapeutics with sonogenetics
sonogenetics can non-invasively modulate the cellular activity of neurons expressed with mechano-sensitive proteins in deeper areas of the brain with less spatial selectivity.
Sonogenetics is developing into a powerful tool in synthetic biology.
This article mainly explores the possible mechanisms of ultrasound's mechanical effects, cavitation effects, thermal effects, and the rise of sonogenetics.
Furthermore, burgeoning research areas such as sonogenetics and nanotechnology show promising potential.
Sonogenetics, a method that uses genetic engineering to produce ultrasound-sensitive proteins in target cells, is gaining prominence along with optogenetics, electrogenetics, and magnetogenetics.
Ultrasound technology, synergistically harnessed with genetic engineering and chemistry concepts, has started to open the gateway to the remarkable realm of sonogenetics-a pioneering paradigm for remotely orchestrating cellular functions at the molecular level.
Sonogenetics is an innovative technology that integrates ultrasound with genetic editing to precisely modulate cellular activities in a non-invasive manner.
Sonogenetics is an emerging medical technology that uses acoustic waves to control cells through sonosensitive mediators (SSMs) that are genetically encoded, thus remotely and non-invasively modulating specific molecular events and/or biomolecular functions.
Our findings demonstrate that sonogenetics can deliver millisecond pattern presentations via an approach less invasive than current brain-machine interfaces for visual restoration.
Sonogenetics is an emerging approach that harnesses ultrasound for the manipulation of genetically modified cells.
These findings provide a mechanistic explanation for the effect of ultrasound on neurons to facilitate the further development of ultrasonic neuromodulation and sonogenetics as tools for neuroscience research.
Collectively, we demonstrate that hsTRPA1-based sonogenetics can effectively manipulate neurons within the intact mammalian brain, a method that could be used across species.
Sonogenetics refers to the use of genetically encoded, ultrasound-responsive mediators for noninvasive and selective control of neural activity.
Current sonogenetic approaches use ultrasound as a non-invasive tool to precisely control cellular function.
Supporting Sources
Linked Claims
Sonogenetics uses genetic engineering to achieve precise neuronal activation.
Advancements in photoacoustic and related optical or acoustic neuromodulation technologies may enhance nerve function remodeling and improve outcomes in spinal cord injury.
Sonogenetics is a promising tool for research and therapeutic applications.
Advanced ultrasound control systems in sonogenetics and gas vesicle-based technologies are presented for applications including cancer therapy, neural activity modulation, visual recovery, and functional imaging.
Neuromodulation techniques have shown significant advancements in treating neurological and psychiatric disorders.
Sonogenetics is developing into a powerful tool in synthetic biology.
The review categorizes neuromodulation techniques into genetic methods and non-genetic methods.
Focused ultrasound has already been clinically applied for targeted brain ablation using high-intensity focused ultrasound and for neuromodulation using low-intensity focused ultrasound, while sonogenetics and BBB-targeted drug delivery are presented as emerging translational opportunities.
Quoted textsource-backed
Currently, FUS has been clinically applied for targeted brain ablation (high intensity [HIFU]) and neuromodulation (low intensity [LIFU]), with recent basic science applications of sonogenetics and targeted drug delivery through the BBB (Precise Intracerebral Noninvasive Guided, or PING, Surgery) offering new opportunities for clinical translation.
Compared with optogenetics, sonogenetics overcomes limits of tissue penetration and invasiveness.
Ultrasound is highlighted as a non-invasive, cost-effective, convenient control modality with high spatiotemporal precision and deep penetration.
Key challenges in ultrasound-guided cellular control include standardization of parameters and understanding of underlying mechanisms.
Fully harnessing the therapeutic potential of neuromodulation requires integration and innovation in technologies, optimization of delivery methods, improvement of mediums, and evaluation of toxicity.
Ultrasound-responsive therapeutic nanomaterials are limited by complex functionalities and toxicity issues, which constrain development of ultrasound control systems.
Coupling ultrasound with genetically engineered effectors enables non-invasive and precise control of cellular and molecular processes.
The tunable thermal and mechanical effects of ultrasound serve as the main triggering sources for engineered cells to perform sono-thermal or sono-mechanical genetic modifications in targeted tissue.
Integrating bacterial therapeutics with sonogenetics provides precise, controllable, and non-invasive tumor killing.
Quoted textsource-backed
This new strategy integrates bacterial therapeutics with sonogenetics, which provides the capability of achieving precise, controllable, and non-invasive killing of tumors.
Sonogenetics and magnetogenetics have demonstrated high specificity and temporal precision in targeting neuronal populations.
Sonogenetics and odourgenetics are described as developed based on optogenetics and chemogenetics.
Quoted textsource-backed
describes the current state of research on sonogenetics and odourgenetics developed based on optogenetics and chemogenetics
Sonogenetics offers targeted spatiotemporal manipulation for gene and cell-based therapies because it is noninvasive, has a high level of safety, and penetrates deep tissue.
Sonogenetics has potential applications including tumor immunotherapy, mitigation of Parkinsonian symptoms, modulation of neural reward pathways, and restoration of vision.
Sonogenetics has potential applications in neuromodulation, oncologic treatments, stem cell therapy, neurological disorders, cancer, ophthalmic diseases, and stem cell therapies.
Quoted textsource-backed
This technology broadens the scope of non-surgical interventions across a wide range of clinical research and therapeutic applications, including neuromodulation, oncologic treatments, stem cell therapy, and beyond... the technique's potential in managing conditions such as neurological disorders, cancer, and ophthalmic diseases, and in stem cell therapies.
The review states that sonogenetics is being used in chronic disease-related contexts including Parkinson's disease, vision restoration, and cancer therapy.
Quoted textsource-backed
Sonogenetics is currently being used extensively in the treatment of various chronic diseases, including Parkinson's disease, vision restoration, and cancer therapy.
Sonogenetics is presented as a paradigm for remotely orchestrating cellular functions at the molecular level using ultrasound combined with genetic engineering and chemistry.
Quoted textsource-backed
Ultrasound technology, synergistically harnessed with genetic engineering and chemistry concepts, has started to open the gateway to the remarkable realm of sonogenetics-a pioneering paradigm for remotely orchestrating cellular functions at the molecular level.
Sonogenetic tools can harness mechanical force within small tissue volumes while preserving surrounding physiological integrity and can reach depths of up to tens of centimeters with high spatiotemporal precision.
Quoted textsource-backed
Sonogenetic tools harness mechanical force within small tissue volumes while preserving the integrity of the surrounding physiological environment, reaching depths of up to tens of centimeters with high spatiotemporal precision.
Sonogenetic capabilities are stated to circumvent physical limitations of optogenetics and magnetogenetics for in vivo control.
Quoted textsource-backed
These capabilities circumvent the inherent physical limitations of alternative in vivo control methods such as optogenetics and magnetogenetics.
Sonogenetics offers enhanced spatial selectivity compared with traditional ultrasound modalities, improving precision and safety in disease treatment.
Quoted textsource-backed
Unlike traditional ultrasound modalities, sonogenetics offers enhanced spatial selectivity, improving precision and safety in disease treatment.
The review states that sonogenetic capabilities circumvent inherent physical limitations of alternative in vivo control methods such as optogenetics and magnetogenetics.
Quoted textsource-backed
These capabilities circumvent the inherent physical limitations of alternative in vivo control methods such as optogenetics and magnetogenetics.
Sonogenetics integrates ultrasound with genetic editing to precisely modulate cellular activities in a non-invasive manner.
Quoted textsource-backed
Sonogenetics is an innovative technology that integrates ultrasound with genetic editing to precisely modulate cellular activities in a non-invasive manner.
Sonogenetics uses acoustic waves and genetically encoded sonosensitive mediators to control cells and remotely, non-invasively modulate molecular events or biomolecular functions.
Sonogenetics uses genetic engineering to produce ultrasound-sensitive proteins in target cells.
Quoted textsource-backed
Sonogenetics, a method that uses genetic engineering to produce ultrasound-sensitive proteins in target cells
Sonogenetics entails introducing mechanosensitive channels into specific cell membranes using gene delivery vectors and activating those channels with ultrasound to affect cellular functions.
Quoted textsource-backed
This method entails introducing and activating mechanosensitive channels on the cell membrane of specific cells using gene delivery vectors. When exposed to ultrasound, these channels can be manipulated to open or close, thereby impacting cellular functions.
Ultrasound stimulation of the expressed ultrasound-sensitive proteins triggers cellular activities and functions.
Quoted textsource-backed
Upon stimulation with ultrasound, these proteins trigger a cascade of cellular activities and functions.
Mechanosensitive ion channels are described as the most commonly utilized sonogenetic mediators.
Quoted textsource-backed
In this review, we first discuss mechanosensitive ion channels, the most commonly utilized sonogenetic mediators, in both mammalian and non-mammalian systems.
Sonogenetic tools harness mechanical force within small tissue volumes while preserving surrounding physiological integrity and can reach depths of up to tens of centimeters with high spatiotemporal precision.
Quoted textsource-backed
Sonogenetic tools harness mechanical force within small tissue volumes while preserving the integrity of the surrounding physiological environment, reaching depths of up to tens of centimeters with high spatiotemporal precision.
Sonogenetics and nanotechnology are described as promising emerging research areas related to low-intensity focused ultrasound neuromodulation.
Quoted textsource-backed
Furthermore, burgeoning research areas such as sonogenetics and nanotechnology show promising potential.
State-of-the-art sonogenetic approaches include strategies that leverage thermal or mechanical features of ultrasonic waves.
Quoted textsource-backed
Subsequently, we provide a comprehensive overview of state-of-the-art sonogenetic approaches that leverage thermal or mechanical features of ultrasonic waves.
Ultrasound enables non-invasive stimulation of deep tissues and is particularly advantageous for brain stimulation.
Quoted textsource-backed
The great penetrability of ultrasound waves enables the non-invasive application of external stimuli to deep tissues, particularly advantageous for brain stimulation.
Sonogenetics can deliver millisecond pattern presentations through an approach described as less invasive than current brain-machine interfaces for visual restoration.
Sonogenetics uses ultrasound to manipulate genetically modified cells.
Quoted textsource-backed
Sonogenetics is an emerging approach that harnesses ultrasound for the manipulation of genetically modified cells.
Genetically encoded ultrasound mediators are critical determinants of sonogenetic effectiveness and applications.
Quoted textsource-backed
Genetically encoded ultrasound mediators, a set of proteins that respond to ultrasound-induced bio-effects, play a critical role in determining the effectiveness and applications of sonogenetics.
In vivo sonogenetic activation of the visual cortex generated a behavior associated with light perception.
Sonogenetics is a promising tool for studying neural circuits.
Quoted textsource-backed
It is a promising tool for studying neural circuits.
The mechanistic findings are presented as enabling further development of ultrasonic neuromodulation and sonogenetics for neuroscience research.
Quoted textsource-backed
These findings provide a mechanistic explanation for the effect of ultrasound on neurons to facilitate the further development of ultrasonic neuromodulation and sonogenetics as tools for neuroscience research.
hsTRPA1-based sonogenetics can effectively manipulate neurons within the intact mammalian brain.
Sonogenetics uses genetically encoded ultrasound-responsive mediators for noninvasive and selective control of neural activity.
Quoted textsource-backed
Sonogenetics refers to the use of genetically encoded, ultrasound-responsive mediators for noninvasive and selective control of neural activity.
Sonogenetics remains an immature field in which basic studies and development are still underway, including evaluation of in vivo spatiotemporal resolution, selectivity, specificity, and safety.
Quoted textsource-backed
However, due to its infancy, basic studies and developments are still underway, including gauging key in vivo performance metrics such as spatiotemporal resolution, selectivity, specificity, and safety.
Sonogenetics has potential therapeutic applications for biological research and medicine and may translate from in vitro and in vivo investigations to clinical therapies.
Quoted textsource-backed
we summarized the introduction of sound waves, the mechano-sensitive proteins commonly used in sonogenetics, and potential therapeutic applications of sonogenetics for biological research and medicine. This short review would beneficiate in the translation of sonogenetics from present in-vitro and in-vivo investigations to clinical therapies.
Sonogenetics is presented as a non-invasive approach for precise control of cellular function.
Quoted textsource-backed
Current sonogenetic approaches use ultrasound as a non-invasive tool to precisely control cellular function.
Sonogenetics includes development of mechano-sensitive proteins, gene introduction into specific cells, targeted stimulation, and outcome readout.
Quoted textsource-backed
In general, sonogenetics includes the development of mechano-sensitive proteins, approaches for introducing their genes to specific cells, targeted stimulation, and finally, reading the outcome.
Sonogenetics combines ultrasonic neuromodulation with mechanosensitive channel protein.
Little information about sonogenetics is currently available.
Sonogenetics may markedly increase the precision and spatial resolution of ultrasonic neuromodulation.
Sonogenetics is applied as a non-invasive approach to control neuronal activity.
Quoted textsource-backed
As a non-invasive approach, sonogenetics is applied to control neuronal activity.
Sonogenetics activates mechanosensitive channels expressed in targeted neurons using low-intensity ultrasound to achieve neuromodulation.
Quoted textsource-backed
Sonogenetics is the technique that activates the MSC expressed in targeted neurons by low intensity ultrasound, thus achieve the neuromodulation.
Recent biomolecular tools are beginning to allow ultrasound to connect directly to cellular functions such as gene expression.
Quoted textsource-backed
Recent advances are beginning to address this limitation through the development of biomolecular tools that allow ultrasound to connect directly to cellular functions such as gene expression.
Optogenetics, magnetogenetics, and sonogenetics are emerging techniques considered exciting future possibilities for Parkinson's disease treatment.
Quoted textsource-backed
Newer techniques being developed (optogenetics, magnetogenetics, and sonogenetics) are exciting possibilities for the future.
Light-responsive proteins are difficult to use outside optically transparent model systems, cultured cells, or surgically accessed regions because biological tissue strongly scatters light.
Quoted textsource-backed
Currently, the most sophisticated tools available to dynamically monitor and control cellular events rely on light-responsive proteins, which are difficult to use outside of optically transparent model systems, cultured cells, or surgically accessed regions owing to strong scattering of light by biological tissue.
Whole brain imaging, optogenetics, sonogenetics, and mutant analysis have allowed interrogation of local and global neural circuits leading to different behaviors in C. elegans.
Quoted textsource-backed
whole brain imaging, optogenetics, sonogenetics and mutant analysis, which have allowed for interrogations of both local and global neural circuits, leading to different behaviors
Sonogenetics is a non-invasive approach to activating neurons in Caenorhabditis elegans.
Quoted textsource-backed
Sonogenetics is a non-invasive approach to activating neurons in Caenorhabditis elegans