spatiotemporal control of engineered bacteria

Certain anaerobic microorganisms are promising candidates for targeted antitumour therapy delivery because they thrive in the hypoxic and immunosuppressive microenvironment of solid tumours.

Bacterial-based drug delivery systems can be engineered to produce and secrete therapeutics without intricate post-purification or protective delivery methods, in contrast to traditional nanodrug delivery systems.

Engineering bacteria that can rapidly and precisely switch between on and off states is an ideal strategy to enable recognition of and reaction to targeted stimuli.

Precise spatiotemporal bacterial control for tumour-site drug delivery can be achieved using inducible or repressible systems that regulate gene expression at specific times and locations.

Engineered bacteria can migrate beyond their intended niche, causing off-target drug release and substantial toxicity to healthy tissues.