First-pass extracted concept

Spinal Trigeminal Nucleus Caudalis projection neurons targeting the parabrachial nucleus

Candidate: concept label1 source documents7 linked claims

Jump to evidence Jump to sources Jump to claims

Live refresh every 5sNext refresh in 5s

Aliases

Sp5C PNs that project to the PBN, Sp5C projection neurons

Evidence Snippets

for identifying and analysing Sp5C PNs that project to the PBN

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2025MEDDOI PubMed

1 evidence snippet 7 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1age dependencesupports2025Source 1DOI PubMed

Retrograde labeling of Sp5C projection neurons was greater when injections were made in young adult animals.

Claim 2comparative observationsupports2025Source 1DOI PubMed

Within Sp5C, rgAAV and AAV9 produced similar levels of projection-neuron labeling in superficial and deep regions.

Claim 3distribution observationsupports2025Source 1DOI PubMed

For both serotypes, labeled Sp5C projection neurons were found bilaterally with a strong ipsilateral bias.

Claim 4genetic access demosupports2025Source 1DOI PubMed

Cre-dependent recombination successfully enabled selective channelrhodopsin-2 expression in Sp5C projection neurons.

Claim 5overall conclusionsupports2025Source 1DOI PubMed

rgAAV and AAV9 produce strong Sp5C projection-neuron transduction and provide a basis for future study of Sp5C projection-neuron afferent and efferent functions.

Claim 6performance observationsupports2025Source 1DOI PubMed

Following unilateral PBN injections, both rgAAV and AAV9 retrogradely labeled many Sp5C projection neurons.

Claim 7utility validationsupports2025Source 1DOI PubMed

rgAAV and AAV9 were evaluated as viral serotypes for identifying and analyzing Sp5C projection neurons that project to the parabrachial nucleus.