Steroidogenic Factor 1 (SF-1, NR5A1) is a nuclear receptor and master regulator of steroidogenic gene expression.
First-pass extracted concept
Steroidogenic Factor-1
Candidate: concept label1 source documents5 linked claims
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Aliases
NR5A1, SF-1
Evidence Snippets
Supporting Sources
Linked Claims
Several signaling lipids have been proposed as potential regulatory ligands of Steroidogenic Factor-1, including sphingosine, lyso-sphingomyelin, sphingomyelin, ceramide, PI(4,5)P2, and PI(3,4,5)P3.
Quoted textsource-backed
Several signaling lipids have been put forth as potential regulatory ligands of SF-1, including sphingosine, lyso-sphingomyelin, sphingomyelin, ceramide and several phosphoinositide species including PI(4,5)P2 and PI(3,4,5)P3.
Hyperactivation of Steroidogenic Factor-1 is associated with adrenocortical carcinoma.
Quoted textsource-backed
hyperactivation of SF-1 associates with adrenocortical carcinoma
Hypomorphic loss-of-function polymorphisms in Steroidogenic Factor-1 are associated with disorders of sexual development.
Quoted textsource-backed
hypomorphic loss-of-function polymorphisms associate with disorders of sexual development
Steroidogenic Factor-1 is a nuclear receptor and master regulator of steroidogenic gene expression.
Quoted textsource-backed
Steroidogenic Factor 1 (SF-1, NR5A1) is a nuclear receptor and master regulator of steroidogenic gene expression.
The endogenous regulatory lipid ligands for Steroidogenic Factor-1 are not yet well established.
Quoted textsource-backed
the identity of the endogenous regulatory lipid ligands for SF-1 have yet to be well established