First-pass extracted concept

stimulus-responsive enzymes

Candidate: concept label1 source documents4 linked claims

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Evidence Snippets

These studies have not only provided insights into the functional role of protein motions, but they offer opportunities to create stimulus-responsive enzymes. These enzymes can be engineered to respond to a number of external stimuli, including light, pH, and the presence of novel allosteric modulators.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2018Protein ScienceDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1application potentialsupports2018Source 1DOI PubMed

Engineering and controlling enzyme structural dynamics offers opportunities to create stimulus-responsive enzymes.

Claim 2application potentialsupports2018Source 1DOI PubMed

The ability to engineer and control enzyme structural dynamics can provide new tools for biotechnology and medicine.

Claim 3mechanistic rolesupports2018Source 1DOI PubMed

Enzyme internal motions are often important for function, including ligand binding, ligand dissociation, and preparation of the active site for catalysis.

Claim 4stimulus scopesupports2018Source 1DOI PubMed

Stimulus-responsive enzymes can be engineered to respond to light, pH, and novel allosteric modulators.