stress-induced reinstatement of drug seeking

This is a preclinical behavioral framework used to model relapse-like drug seeking triggered by stress. The review presents it as a long-standing rat model that also extends to conditioned place preference settings in rats and mice.

The abstract supports use in animal behavioral procedures including rats trained to self-administer heroin and conditioned place preference models in rats and mice.

It provides an experimental way to study how stress provokes relapse-like drug seeking and craving-related behavior.

The review indicates the phenomenon is stressor specific, so it does not imply that every stressor will reproduce reinstatement.

The abstract contrasts different behavioral procedures, including self-administration and conditioned place preference, but does not present a single alternative as superior.