First-pass extracted concept

stress susceptibility

Candidate: concept label2 source documents4 linked claims

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Evidence Snippets

Here, we review evidence from both animal models and humans that is increasingly revealing the neurophysiological and neuropsychological mechanisms that underlie stress susceptibility, as well as active mechanisms underlying the resilience phenotype.

Evidence 1Source 1DOI PubMedprovenance

a relatively small proportion of people (10-20%) experiencing prolonged stress develop stress-related psychiatric disorders, including depression (susceptibility to stress)

Evidence 2Source 2DOI PubMedprovenance

Supporting Sources

Source 1review2018Frontiers in Human NeuroscienceDOI PubMed

1 evidence snippet 1 linked claim Claim 1

Source 2review2017NeurotherapeuticsDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1review summarysupports2018Source 1DOI PubMed

Evidence from animal models and humans is revealing neurophysiological and neuropsychological mechanisms underlying both stress susceptibility and resilience.

Claim 2review summarysupports2017Source 2DOI PubMed

Accumulating evidence implicates genetic, epigenetic, and neurophysiological mechanisms in stress susceptibility and active mechanisms in resilience.

Quoted textsource-backed

An accumulating body of evidence is revealing the genetic, epigenetic, and neurophysiological mechanisms that underlie stress susceptibility, as well as the active mechanisms that underlie the resilience phenotype.

Claim 3review summarysupports2017Source 2DOI PubMed

Only a minority of people exposed to prolonged stress develop stress-related psychiatric disorders including depression, while most maintain normal psychological functioning, indicating variation between susceptibility and resilience.

Quoted textsource-backed

a relatively small proportion of people (10-20%) experiencing prolonged stress develop stress-related psychiatric disorders, including depression (susceptibility to stress), whereas most stress-exposed individuals maintain normal psychological functioning (resilience to stress)

Claim 4translational implicationsupports2017Source 2DOI PubMed

Pathological mechanisms of susceptibility are identified as potential therapeutic targets for depression treatment, and resilience-promoting mechanisms are reviewed as an alternative therapeutic strategy.

Quoted textsource-backed

key pathological mechanisms of susceptibility that are identified as potential therapeutic targets for depression treatment. We also review novel mechanisms that promote natural resilience as an alternative strategy to achieve treatment efficacy.