First-pass extracted concept

striatal tyrosine hydroxylase interneurons

Candidate: concept label1 source documents4 linked claims

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Aliases

striatal TH interneurons, THINs

Evidence Snippets

This demonstrates that striatal TH interneurons do not release DA.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2015Journal of NeuroscienceDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1cell identitysupports2015Source 1DOI PubMed

Striatal tyrosine hydroxylase interneurons are not dopaminergic but are a type of GABAergic interneuron.

Quoted textsource-backed

These results indicate that striatal TH interneurons are not dopaminergic but rather are a type of GABAergic interneuron

Claim 2cell identitysupports2015Source 1DOI PubMed

Striatal tyrosine hydroxylase interneurons do not release dopamine.

Quoted textsource-backed

This demonstrates that striatal TH interneurons do not release DA.

Claim 3functional effectsupports2015Source 1DOI PubMed

Optogenetic activation of striatal EGFP-TH interneurons produces strong GABAergic inhibition in spiny neurons.

Quoted textsource-backed

Optogenetic activation of striatal EGFP-TH interneurons produced strong GABAergic inhibition in all spiny neurons tested.

Claim 4marker profilesupports2015Source 1DOI PubMed

Striatal EGFP-TH interneurons do not colocalize with dopamine, aromatic L-amino acid decarboxylase, dopamine transporter, or vesicular monoamine transporter-2.

Quoted textsource-backed

Fluorescence immunocytochemistry in enhanced green fluorescent protein (EGFP)-TH mice revealed colocalization of DA, l-amino acid decarboxylase, the DA transporter, and vesicular monoamine transporter-2 with EGFP in midbrain dopaminergic neurons but not in any of the striatal EGFP-TH interneurons.