First-pass extracted concept

sulfane sulfur

Candidate: concept label1 source documents4 linked claims

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Aliases

persulfide (R-SSH), polysulfide (R-SnH, n ≥ 2), zero-valent sulfur

Extracted Explainers

What the tool is doing

The abstract presents sulfane sulfur as a bacterial cellular component whose changing levels affect expression of many MarR-controlled genes.

Source 1DOI PubMed

Resources required

Not applicable from the abstract because sulfane sulfur is discussed as a biological signal, not as a toolkit item.

Source 1DOI PubMed

What problem it solves

The review uses sulfane sulfur to explain modulation of MarR-family regulators whose activities were not fully explained by previously characterized modulators.

Source 1DOI PubMed

What it does not solve

The abstract does not describe sulfane sulfur as an engineered reagent, assay, or deployable tool.

Source 1DOI PubMed

Alternatives

Reactive oxygen species are mentioned as a related signal class because both ROS and sulfane sulfur can induce disulfide bond formation.

Source 1DOI PubMed

Evidence Snippets

Several MarR family proteins have been reported to sense sulfane sulfur, including zero-valent sulfur, persulfide (R-SSH), and polysulfide (R-SnH, n ≥ 2).

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2024MEDDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1chemical mechanismsupports2024Source 1DOI PubMed

Sulfane sulfur reacts with cysteine thiols of MarR family proteins to form protein thiol persulfide, disulfide bonds, and other modifications.

Quoted textsource-backed

Sulfane sulfur reacts with the cysteine thiols of MarR family proteins, causing the formation of protein thiol persulfide, disulfide bonds, and other modifications.

Claim 2mechanistic overlapsupports2024Source 1DOI PubMed

Several MarR family proteins that respond to reactive oxygen species also sense sulfane sulfur because both signals induce disulfide bond formation.

Quoted textsource-backed

Several MarR family proteins that respond to reactive oxygen species (ROS) also sense sulfane sulfur, as both sulfane sulfur and ROS induce the formation of disulfide bonds.

Claim 3regulatory effectsupports2024Source 1DOI PubMed

Changing sulfane sulfur levels affect expression of many MarR-controlled genes in bacteria.

Quoted textsource-backed

Sulfane sulfur is a common cellular component in bacteria whose levels vary during bacterial growth. The changing levels of sulfane sulfur affect the expression of many MarR-controlled genes.

Claim 4sensing mechanismsupports2024Source 1DOI PubMed

Several MarR family proteins sense sulfane sulfur.

Quoted textsource-backed

recently, several MarR family proteins have been reported to sense sulfane sulfur