The source title identifies the Surviving Sepsis Campaign as the framework for international guidelines on severe sepsis and septic shock management.
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Surviving Sepsis Campaign
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To provide an update to the "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," last published in 2008.
Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008
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The authors conclude that evidence-based recommendations for acute management of sepsis and septic shock are the foundation of improved outcomes.
Quoted textsource-backed
evidence-based recommendations regarding the acute management of sepsis and septic shock are the foundation of improved outcomes for this important group of critically ill patients
The guideline recommends administration of broad-spectrum antimicrobials within 1 hour of recognition of septic shock and severe sepsis without septic shock.
Quoted textsource-backed
administration of broad-spectrum antimicrobials therapy within 1 h of the recognition of septic shock (1B) and severe sepsis without septic shock (1C) as the goal of therapy
The guideline recommends crystalloid for initial fluid resuscitation and recommends avoiding hetastarch formulations.
Quoted textsource-backed
initial fluid resuscitation with crystalloid (1B) and consideration of the addition of albumin in patients who continue to require substantial amounts of crystalloid to maintain adequate mean arterial pressure (2C) and the avoidance of hetastarch formulations (1B)
The guideline recommends early quantitative resuscitation during the first 6 hours after recognition of sepsis.
Quoted textsource-backed
early quantitative resuscitation of the septic patient during the first 6 h after recognition (1C)
The guideline recommends norepinephrine as the first-choice vasopressor to maintain mean arterial pressure of at least 65 mmHg.
Quoted textsource-backed
norepinephrine as the first-choice vasopressor to maintain mean arterial pressure ≥65 mmHg (1B)
The guideline organizes recommendations around major management domains including early goal-directed resuscitation, early antibiotics and source control, hemodynamic support, corticosteroids, recombinant human activated protein C, transfusion thresholds and blood products, lung-protective ventilation, glucose control, renal replacement therapy, bicarbonate, prophylaxis measures, and sedation or weaning.
Quoted textsource-backed
The article explicitly organizes recommendations around major management domains including early goal-directed resuscitation, early antibiotics/source control, fluids/vasopressors/inotropes, corticosteroids, recombinant human activated protein C, transfusion thresholds/blood products, lung-protective ventilation, glucose control, renal replacement therapy, bicarbonate, DVT/stress-ulcer prophylaxis, and sedation/weaning.
This paper presents international guidelines for management of severe sepsis and septic shock.
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Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008