While the effects of vascular Aβ accumulation are better documented, the scientific community has only recently started to consider the impact of tau on neurovascular pathology in AD.
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tau-driven neurovascular pathology
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The review postulates that tau can initiate neurovascular pathology in Alzheimer's disease through mitochondrial dysregulation.
The review synthesizes cellular, animal, and human evidence linking tau pathology to malfunction of the brain vasculature and neurovascular unit, including associations with mitochondrial alterations and caspase activation.
Cerebrovascular dysfunction is an early feature of Alzheimer's disease pathology.
Emerging evidence indicates that neuronal tau can spread to other brain cells and into interstitial fluid, potentially leading to perivascular tau accumulation and toxicity that affects vessel architecture, cerebral blood flow, and vascular permeability.
Pathological tau may impair blood-brain barrier integrity and functionality, potentially accelerating Alzheimer's disease progression.