First-pass extracted concept

TAX1BP1

Candidate: concept label1 source documents4 linked claims

Jump to evidence Jump to sources Jump to claims

Live refresh every 5sNext refresh in 5s

Aliases

Tax1 (human T cell leukemia virus type I) binding protein 1

Evidence Snippets

TAX1BP1 is a selective macroautophagy/autophagy receptor that plays a central role in host defense to pathogens and in regulating the innate immune system.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2022AutophagyDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1autophagosome biogenesis summarysupports2022Source 1DOI PubMed

Beyond canonical receptor functions, TAX1BP1 is described as having accessory functions that influence autophagosome biogenesis and maturation.

Claim 2functional role summarysupports2022Source 1DOI PubMed

TAX1BP1 is described as a selective autophagy receptor with central roles in host defense and innate immune regulation.

Claim 3pathogen clearance summarysupports2022Source 1DOI PubMed

The review states that TAX1BP1 facilitates xenophagic clearance of pathogenic bacteria including Salmonella typhimurium and Mycobacterium tuberculosis.

Claim 4signaling regulation summarysupports2022Source 1DOI PubMed

The review states that TAX1BP1 regulates TLR3-TLR4 and RIG-I-like receptor signaling by targeting TICAM1 and MAVS for autophagic degradation, respectively.