First-pass extracted concept

TgBipA

Candidate: concept label1 source documents5 linked claims

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Aliases

TgME49_301380

Extracted Explainers

What the tool is doing

TgBipA is described as an apicoplast-localized homolog of the conserved bacterial translational GTPase BipA. The paper characterizes it as essential for apicoplast maintenance and parasite survival.

Source 1DOI PubMed

Evidence Snippets

In this study, we characterized a NEAT protein named TgBipA, which is a homolog of the highly conserved prokaryotic translational GTPase BipA.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2026MEDDOI PubMed

1 evidence snippet 5 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1biochemical activitysupports2026Source 1DOI PubMed

TgBipA is an active GTPase in vitro and its GTP hydrolysis activity is critical for cellular function.

Claim 2essentialitysupports2026Source 1DOI PubMed

TgBipA is essential for Toxoplasma gondii survival.

Claim 3localizationsupports2026Source 1DOI PubMed

TgBipA is an apicoplast-localized GTPase homologous to prokaryotic BipA.

Claim 4loss of function phenotypesupports2026Source 1DOI PubMed

Loss of TgBipA causes apicoplast genome replication defects, disruption of NEAT trafficking, loss of the apicoplast, and parasite death.

Claim 5phenotype similaritysupports2026Source 1DOI PubMed

The TgBipA loss phenotype closely resembles the delayed death phenomenon observed when apicoplast translation is inhibited.